Nail Lacquers (transungal) as a Drug Delivery System
ثبت نشده
چکیده
The medicated lacquer preparations are generally used in fungal diseases. Use of this system avoids oral toxicity of anti fungal drugs. The main challenge associated with developing nail lacquers for the treatment of nail disorders is to deliver the active concentration to the site of infection. Penetration of topical antifungal through the nail plate requires a vehicle that is specially formulated for transungual delivery.
منابع مشابه
Amorolfine vs. ciclopirox – lacquers for the treatment of onychomycosis
Amorolfine 5% and ciclopirox 8% nail lacquers are commonly used in topical treatment of onychomycosis. These formulations may be used alone or in combination with oral antifungal agents. Amorolfine and ciclopirox are valuable therapeutic options, however, their usage in monotherapy should be limited. Proper amorolfine and ciclopirox penetration through the nail plate is provided by transungual ...
متن کاملEffect of a novel penetration enhancer on the ungual permeation of two antifungal agents.
OBJECTIVES The aim of this study was to demonstrate the effect of a novel permeation enhancer system using two existing marketed nail lacquers and the delivery of terbinafine through human nail samples in vitro. METHODS Initially a modified Franz cell was used, where sections of human nail serve as the barrier through which drug penetrates into an agar-filled chamber infected with dermatophyt...
متن کاملOnychomycosis: Potential of Nail Lacquers in Transungual Delivery of Antifungals
Onychomycosis constitutes the most common fungal infection of the nail (skin beneath the nail bed) that affects the finger as well as toe nails. It is an infection that is initiated by yeasts, dermatophytes, and nondermatophyte molds. Nail lacquers are topical solutions intended only for use on fingernails as well as toenails and have been found to be useful in the treatment of onychomycosis. T...
متن کاملAntifungal potential of tolnaftate against Candida albicans in the treatment of onychomycosis: development of nail lacquer and ex vivo characterization
Onychomycosis constitutes the most common fungal infection of nail affecting finger and toe nails as well. Antifungals found to be effective in the treatment of onychomycosis. However, transport of oral antifungal agents exhibits more toxicity and requires longer treatment period. Medicated nail lacquers proved to cause lesser toxicity and required shorter treatment period. It provides not only...
متن کاملEvaluation of different setups for the measurement of drug penetration into the nail
Topical therapy of onychomycosis, a fungal infection of nail plate and/or nail bed, offers an attractive alternative to treatment with systemic antifungals. To treat fungal infections locally, antifungal-loaded nail lacquers have been prepared in our laboratory. Franz diffusion cells have been used to investigate drug permeation from such lacquers into and through the nail plate in vitro. Altho...
متن کامل